Efficient preparation of α-ketoacetals.
نویسندگان
چکیده
The Weinreb amides 2a,b were prepared from the α,α-dimethoxyacetic acids 1c,d. A number of representative nucleophilic additions (RMgX and RLi) on 2 afforded α-ketoacetals 3a-j in 70-99% yield. These compounds represent a versatile arrangement of functional groups of significant synthetic value, as demonstrated in the synthesis of (±)-salbutamol.
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ورودعنوان ژورنال:
- Molecules
دوره 17 12 شماره
صفحات -
تاریخ انتشار 2012